Join Ash accompanied by his partner Pikachu, as he travels through many regions, meets new friends and faces new challenges on his quest to become a Pokémon Master.
Ash goes to a flower garden to get some fertilizer for his mother, but Bulbasaur sniffs the flowers and becomes paralyzed.
When the gang discovers there is a movie with an all-Pokémon cast being made nearby, Ash and his friends put their Pokémon in for an audition. Misty's Psyduck gets the main role while the others get minor roles.
Ash and his friends go to Hollywood (although only a small nearby town) to see the premiere of the movie their Pokémon were cast in. Team Rocket follows them to find out that Meowth has history in this town; It is here where he was a member of a gang of street Meowths led by the Persian. He learned to speak and walk upright to win the heart of a female Meowth who was abandoned by her owner. Upon returning, he challenges Persian who was once his mentor for the female Meowth he thought he lost years before.
After watching Elite Four member Bruno on TV, Ash and his friends decide to do training in the mountains to be as strong as Bruno. However, they meet Bruno and he manipulates them to do some menial tasks for him. Meanwhile, a giant Onix is on a rampage.
While training, Ash and his friends accidentally uncover the ruins of Pokémopolis, an ancient city. After a bit of research, they find a giant Gengar and a giant Alakazam starting to fight. Then, a giant Jigglypuff appears to put them to sleep.
Ash and his friends offer to help a trainer that is heading for the Pokémon League to retrieve his stolen gym badges from Team Rocket.